Recent years have brought additional data on the benefits of prebiotics and probiotics treatment in patients with atopic dermatitis. This review includes all the articles published in PubMed, Scopus, Embase and Cochrane databases until 05.06.2018. The terms used for the search were 'prebiotic', 'probiotic', 'atopic dermatitis', 'Severity Scoring of Atopic Dermatitis', and 'SCORAD'. There was an increase of the intestinal permeability reported in patients with atopic dermatitis and a reduction of the cutaneous microbiome diversity. Probiotics modulate the general microbiome and immune status by improving the intestinal barrier; these effects can be responsible for reducing allergic phenomenon and atopic dermatitis severity. We have structured the results by age groups as infants, 1-18 years, adults, and also pregnancy and lactation. Literature does not offer yet answers on the issues such as the optimal dosing, duration needed to see beneficial effects, the optimal time to start the treatment; the personalized use of probiotics according to colonic dysbiosis may be associated with better results. However, most randomized controlled trials and meta-analyzes support the administration of probiotics for at least 8 weeks in order to obtain beneficial effects in improving severity scoring of atopic dermatitis. Contents 1. Introduction 2. Definition of terms 3. Modulating the human microbiome by pre-and probiotics 4. Prebiotic and probiotic in atopic dermatitis 5. The type of probiotics used in clinical trials 6. Prebiotics-mechanism of action 7. Probiotics-mechanism of action 8. Conclusion

AbstractBackground and aim:The Roma population is one of the ethnic minorities with a long history of malnutrition. The aim of this study was to evaluate the prevalence of underweight in Roma population living in rural settlements from Călăraşi County in the south part of Romania.Methods:This cross-sectional, epidemiological, non-interventional study was conducted from March 2014 to May 2017 in several villages from Calarasi County. We analized the data from 978 people: 660 Roma (457 females/203 males), and 318 Romanian Caucasians (213 females/105 males) aged between 18 and 88 yr. Body mass index (BMI) was classified using the definitions of World Health Organization and a BMI < 18.5 kg/m2 was defined as underweight.Results:In Roma population group, the prevalence of underweight, normal weight, overweight and obesity was 4.5% (n = 30), 26.5% (n = 175), 25% (n = 165) and 43.9% (n = 290) respectively. The prevalence of underweight was higher in Roma population compared to Romanian Caucasian, with a significantly higher prevalence in young age groups, 6.9% in 18–29-year age group and 8.2% in 30–39-year age group as well as in the age group of over 70 years (7.5%).Among the Roma population, in multivariate adjustment for all covariates in a backward stepwise elimination procedure, significant predictors of underweight were a current smoking and lower socio-educational level (under eight classes).Conclusions:Our results confirm and reinforce the need to implement prevention programs in high-risk populations such as the Roma population, due to the double burden of malnutrition, low access to the health system, low socio-economic level, limited access to education lack of medical education and preventive healthcare.