Routine electroencephalograms (EEG) are not recommended as a screen for epileptic discharges (EDs) in current practice guidelines for children with autism spectrum disorder (ASD). However, a review of the research from the last three decades suggests that this practice should be reevaluated. The significant comorbidity between epilepsy and ASD, its shared biological pathways, risk for developmental regression, and cognitive challenges demand increased clinical investigation requiring a proactive approach. This review highlights and explains the need for screening EEGs for children with ASD. EEG would assist in differentiating EDs from core features of ASD and could be included in a comprehensive assessment. EEG also meets the demand for evidence-based precision medicine and focused care for the individual, especially when overlapping processes of development are present.

The routine use of stimulants in pediatrics has increased dramatically over the past 3 decades and the long-term consequences have yet to be fully studied. Since 1978 there have been 7 articles identifying electroencephalogram (EEG) abnormalities, particularly epileptiform discharges in children with attention deficit hyperactivity disorder (ADHD). Many have studied the prevalence of these discharges in this population with varying results. An article published in 2011 suggests that EEG technology should be considered prior to prescribing stimulants to children diagnosed with ADHD due to a high prevalence of epileptiform discharges. The 2011 study found a higher prevalence (26%) of epileptiform discharges when using 23-hour and sleep-deprived EEGs in comparison with other methods of activation (hyperventilation or photostimulation) and conventional EEG. We sought to replicate the 2011 results using conventional EEG with the added qEEG technologies of automatic spike detection and low-resolution electromagnetic tomography analysis (LORETA) brain mapping. Our results showed 32% prevalence of epileptiform discharges, which suggests that an EEG should be considered prior to prescribing stimulant medications.

Our results find that compared with the healthy population, a large number of patients with ASD have isolated epileptiform discharges despite never having a seizure. Our findings support the use of EEG in children, adolescents, and young adults with ASD, regardless of gender or age. This is particularly true for those who exhibit aggressive behaviors or those who have failed previous medication attempts with stimulants, antidepressants, and/or antipsychotics.

Research into the benefits of children eating breakfast has previously focused on educational and cognitive performance as well as behavior. Few nutritional investigations have utilized brain imaging technology in order to examine how breakfast influences brain function.This single case study used quantitative electroencephalography (qEEG) in order to assess how three different breakfast choices affected a 12-year-old female's brainwave activity. The three different breakfast conditions included no breakfast, a high-sugar/highcarbohydrate breakfast, and a nutritionally balanced breakfast. The findings indicated that skipping breakfast significantly increased high beta activity associated with anxiety and focus issues. Eating a high-sugar/highcarbohydrate breakfast was also associated with increased high beta activity, but less significant than the nobreakfast option. Most importantly, eating a nutritionally balanced breakfast was found to normalize the qEEG. The variation in high beta activity in the different breakfast options suggested that eating a nutritionally balanced breakfast may reduce anxiety and increase focus compared to skipping breakfast. These results may help explain why previous research has found cognitive, academic, and behavioral improvements when children consume breakfast. Furthermore, the qEEG should be considered in future nutritional studies as a measurement of brain function.Keywords: breakfast; nutrition; qEEG; children; performance; behavior Citation: MacInerney, E. K., Swatzyna, R. J., Roark, A. J., Gonzalez, B. C., & Kozlowski, G. P. (2017). Breakfast choices influence brainwave activity: Single case study of a 12-year-old female. NeuroRegulation, 4(1), 56-62. http://dx

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