Background:As endometrial cancer (EC) prevalence increases with obesity, we aimed to determine whether EC characteristics depend upon obesity type: ‘standard’ (SO) or ‘metabolically healthy obesity’ (MHO).Patients & methods:258 EC patients were included. Data on anthropometry, blood hormones, lipids and glucose, and tumor features were collected.Results:EC clinicopathologic characteristics and clinical stage correlate differently with BMI and obesity type. BMI is related inversely with tumor grade while SO patients are characterized by a more advanced clinical stage than those with MHO. Besides typical insulin resistance signs, EC patients with SO often display a higher serum leptin/adiponectin ratio compared with MHO patients. Historical data suggest a gradual increase in EC patient height and weight, and a decrease in MHO prevalence.Conclusion:It is currently unknown whether the latter observation reflects the evolution of EC, or obesity alongside the current epidemic. Regardless, the reduced MHO prevalence demonstrates the need for more intensive preventive measures aimed at obesity and obesity-associated conditions, including different EC subtypes.

The question hidden in the title of this manuscript (whether the topic develops or remains constant) is important for all areas of science. It is also a serious problem for endometrial cancer (EC) study. In recent times the incidence of EC gradually increases in parallel with obesity epidemics. The main point of this review was evaluation of changes in EC area in last few decades, which are not only seen in tumor incidence, but also in its biology, hormonal-metabolic characteristics of patients and in the ratio of risk and anti-risk factors. One can hope that data accumulated recently and summarized here under the notion of EC evolution will find its use for advancement of EC prevention and treatment.

■ Ключевые слова: рак эндометрия; гормонально-метаболический статус; сравнительная динамическая оценка. ■ Keywords: endometrial cancer; hormonal and metabolic status; a comparative dynamic evaluation. COMPARATIVE EVALUATION OF HORMONAL-METABOLIC STATUS OF ENDOMETRIAL CANCER PATIENT´S OVER THE PAST FIVE DECADES

On the basis of the Department of Oncogynecology together with the pathoanatomical department of the N.N. Petrov Research Institute of Oncology conducted a comparative assessment of age-related features of endometrial cancer. The study included 309 patients, which were divided into two groups: group 1 - from 50 to 69 years (n = 150), group 2 - 70 years and older (n = 159). The article presents a comparative assessment of treatment, morphological characteristics of the tumor and the prevalence of the tumor process in two age groups, as well as the long-term results of treatment.

Aim: Evaluation of changes that have occurred in the ideas in endometrial cancer over the past 10-20 years and their potential applications. Materials and methods: Analysis of modern publications including databases of PubMed and Russian scientific electronic library (http://elibrary.ru) with the use of the information received as a result of own studies. Conclusions: A shifts in the incidence of endometrial cancer, a reform of the views on molecular-biological typing of this tumor, changes in the ratio of its morphological variants as well as in the risk and anti-risk factors were discussed. According to our own data in a group of 144 endometrial carcinomas (endometrioid and non-endometrioid) the frequency of POLEe mutations was equal to 2.8% that might change after increasing of the number of patients. Rapidly accumulating information in this field can be useful for improving approaches to preventing and treatment of endometrial carcinoma.