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Objective: To describe a case of spontaneous intercalary scleromalacia with anterior segment photographs and optical coherence tomography. Methods: A 32-year-old woman attended our ophthalmology department due to progressive bilateral epiphora. Anterior segment photographs, optical coherence tomography and topography were performed, as well as a complete blood count with autoimmunity markers. Results: Anterior segment photographs showed absence of limbal vasculature with scleral thinning and bluish discoloration due to visualization of underlying choroidal tissue. Anterior segment OCT confirmed scleral thinning and microperforations. Topographies and blood tests were normal. Conclusion: Spontaneous intercalary scleromalacia is a rare disorder that consists in progressive scleral thinning with microperforation. The presentation of this disorder varies from asymptomatic to extrusion of ocular contents.