Background: There is evidence showing that marital status (MS) and marital disruption (i.e., separation, divorce, and being widowed) is associated with poor physical health outcomes, including for all-cause mortality. We evaluated the available evidence on the association between MS and cardiovascolar (CV) diseases, outcomes and CV risk factors. Methods: All relevant papers, including the MeSH term 'marital status' in their title, were searched using the PubMed database. Moreover, the crossed search terms were: "cardiovascular diseases", "acute myocardial infarction", "acute coronary syndrome", "coronary artery disease", "cardiac arrest", "heart failure", "heart diseases", "cardiovascular mortality", "cardiovascular risk factors", "hypertension", "cholesterol", "obesity", "smoking", "alcohol", "fitness and/or physical activity", "health". Casereports, comments, discussion letters, abstracts of scientific conferences, articles in other than English language, and conference abstracts or proceedings were excluded. Results: In total, 817 references were found and, according to the inclusion criteria, 35 studies (accounting for a total of 1 245 967 subjects) were considered suitable for analysis. In particular, 23 studies dealt with 'cardiovascular diseases' and 12 with 'cardiovascular risk factors'. Conclusions: The great majority of studies showed better outcomes for married persons compared with single, divorced or widowed persons. Males generally had the poorest outcomes.