This paper presents an assessment of three potential applications of municipal treated wastewater in a semiarid region of northern Mexico. The potential applications considered are agriculture, industry, and watering urban green areas. The results indicate that in the best scenario, the maximal application of treated wastewater is 150 L/s for industrial activities. Besides industrial applications, this scenario would allow farmers and urban green areas to receive 980 L/s and 70 L/s of treated wastewater respectively. Other issues and alternatives are also identified. With the implementation of this scenario, it is possible to improve the environmental, and even the socioeconomic conditions, of the study region.