Orf virus (ORFV), the prototype species of the parapoxvirus genus, is the causative agent of contagious ecthyma, an extremely devastating skin disease of sheep, goats, and humans that causes enormous economic losses in livestock production. ORFV is known for its ability to repeatedly infect both previously infected and vaccinated sheep due to several immunomodulatory genes encoded by the virus that temporarily suppress host immunity. Therefore, the development of novel, safe and effective vaccines against ORFV infection is an important priority. Although, the commercially licensed live-attenuated vaccines have provided partial protection against ORFV infections, the attenuated viruses have been associated with major safety concerns. In addition to safety issues, the persistent reinfection of vaccinated animals warrants the need to investigate several factors that may affect vaccine efficacy. Perhaps, the reason for the failure of the vaccine is due to the long-term adaptation of the virus in tissue culture. In recent years, the development of vaccines against ORFV infection has achieved great success due to technological advances in recombinant DNA technologies, which have opened a pathway for the development of vaccine candidates that elicit robust immunity. In this review, we present current knowledge on immune responses elicited by ORFV, with particular attention to the effects of the viral immunomodulators on the host immune system. We also discuss the implications of strain variation for the development of rational vaccines. Finally, the review will also aim to demonstrate future strategies for the development of safe and efficient vaccines against ORFV infections.

Purpose The purpose of this paper is to investigate the psychosocial perception of harmattan dust on building openings, health and housekeeping to determine the influence of the dust on building occupants. Design/methodology/approach Population-representative survey data were collected from Maiduguri, Northeastern Nigeria, through physical administration of questionnaires by assessing several variables. Statistical package SPSS 16.0 was used for the data analysis, which is mainly descriptive analysis in frequencies, percentages and means together with a repeated Pearson’s chi-square analysis to identify the relationship between the factors and the significance testing. Findings The results show that majority (94.3%) experienced dust problem in harmattan season, and a larger part (76.6%) confirmed that the dust penetrates through doors and windows. Higher percentage (91.2%) noticed that the dust particles on their floor/furniture surfaces, and on an average, people clean their houses three times daily in harmattan season. Majority (80.5%) of the respondents smell dust in the harmattan season, and greater part (77.9%) experienced health challenges in this season, of which 12.8% confirmed harmattan dust aggravates their asthma, 13.6% confirmed it causes headache, 3.1% confirmed it exacerbated pneumonia, 58.5% confirmed it causes coughing, 3.5% confirmed catarrh, 2.3% confirmed nasal/respiratory congestion, sneezing and bronchitis and 6.2% experienced eye problems. Moreover, the results indicate that number/types of openings in a building are significantly associated with factors including smelling dust in the harmattan season and health problem experienced because of dust indoors. The number of times people clean their homes/workplaces is significantly related to important variables such as experiencing dust problem in harmattan season and number/type of openings in a building. The results further established that the health problem experienced by people is significantly related to important variables including dust problem experienced in the harmattan season and type of openings in a room. Originality/value Harmattan dust is a serious challenge to health and well-being of building occupants in the study area. The built environment professionals need to optimize building openings for effective dust control indoors.

Contagious ecthyma (CE) is an infectious disease of small ruminants caused by a parapoxvirus of family Poxviridae subfamily Chordopoxvirinae. The disease is obviously distinguished by an establishment of scabby lesions and ulcerative formation on less hairy areas including muzzle, ears, nostril, and sometimes on genitalia. The disease is endemic in sheep and goats. The virus is transmissible to other ruminants and is a public health concern in humans. Although the disease is known as self-limiting, it may cause a significant economic threat and financial losses due to lower productivity in livestock production. Information with regard to the risk of the disease and epidemiology in most parts of the world is underreported. This paper aims to provide relevant information about the epidemiology of CE in selected regions of Europe, South America, North America, Asia, Africa, and Australia. An in-depth comprehension of virus infection, diagnoses, and management of the disease will enable farmers, researchers, veterinarians, abattoir workers, health personnel, and border controllers to improve their measures, skills, and effectiveness toward disease prevention and control, toward reducing unnecessary economic loss among farmers. A herd health program for significant improvement in management and productivity of livestock demands a well planned extension program that ought to encourage farmers to equip themselves with adequate skills for animal healthcare.

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