The technique of replacing the cement with other alternative materials focus on the production of materials with similar performance and reduced environmental impacts relative to traditional cement. The main aim of this study is to investigate the effect of replacing the cement content with high volume of GGBS and PFA on the mechanical performance of cement mortar. Three mixtures were prepared with different percentages of GGBS and PFA (40%, 60% and 80%) as replacement of cement along with other mixture that made with 100% cement as a control mixture. In order to evaluate the performance of the cement mortars, compressive strength test after 7, 14 and 28 days of curing was used. The results indicated that after 7 days of curing, the increase of GGBS and PFA contents caused a reduction in the compressive strength in comparison with the control mixture. After 28 days of curing, the results indicated that the mixture incorporated 80% GGBS and PFA has higher compressive strength relative to the control mixture. Such findings will significantly contribute in reducing the cost of the produced mortar by reducing the amount of used cement and this consequently reduce the cement demands/manufacturing. Less production of cement will reduce the CO2 emissions of the cement industry.