Introduction and purpose: In schools not performing OSCE method, faculty members' lack of time, human resources and managing the complexity of such exam are the most common obstacles. In this study, we utilized different methods to evaluate the the validity and reliability of a simple diversified OSCE as part of final exam for ambulatory care clerkship along with the theoretical exam. Methods: We analyzed the correlation and difference between students' achievements in the written exam and their achievements in OSCE. We also compared between students' achievements according to each OSCE station they enrolled in. As students' feedback is an important indicator of the success of the learning process, students' feedback about OSCE was also measured. Results: A moderate correlation was observed between students' overall marks in OSCE and that in written exam (r 2 = 0.36 p= 0.001). Prescription station showed a moderate correlation with the written exam (r 2 = 0.30, p < 0.001) and the counseling station showed a weak correlation (r

Background: There is a high prevalence of arterial thrombosis in schizophrenia. Several studies investigated the cause of this high risk among schizophrenic patients and variable finding reported. The aim of this study was to investigate whether second generation antipsychotics (risperidone, olanzapine and ziprasidone) exert antiplatelet action in the presence of different platelet agonists. Methods: We performed an in vitro study of different antipsychotics (risperidone, olanzapine and ziprasidone) effect on platelet aggregation induced by different platelet agonists (ADP, collagen, serotonin and epinephrine) when added to blood of healthy volunteers using Multiplate® analyzer. Results: Risperidone and ziprasidone but not olanzapine showed clinically significant inhibition of platelet aggregation induced by by serotonin, while only ziprasidone showed statistically significant inhibition on serotonin aggregation. All tested antipsychotics showed clinically (but not statistically) significant inhibition on platelet aggregation induced by epinephrine. On the other hand, no remarkable effect of antipsychotics on platelet aggregation induced by ADP or collagen was observed. Marked amplification reaction between serotonin and epinephrine was observed (AUC 66 U). When antipsychotics were added to serotonin-epinephrine combination, all of them produced AUC inhibition in a dose-dependent manner with highest potency for risperidone (IC50= 14.86 nM) and the lowest potency for olanzapine (IC50= 27.56 nM). Conclusion: All tested antipsychotics showed clinically (but not statistically) significant inhibition effect on platelet aggregation induced by either serotonin or epinephrine. All antipsychotics studied inhibited platelet aggregation induced by a combination of serotonin and epinephrine in a dose-dependent manner.