Designing efficient acoustic stack and elements for high-frequency (HF) medical ultrasound (US) transducers involves various interrelated parameters. So far, optimizing spatial resolution and acoustic field intensity simultaneously has been a daunting task in the area of HF medical US imaging. Here, we introduce optimized design for a 50-MHz US probe for skin tissue imaging. We have developed an efficient design and simulation approach using Krimholtz, Leedom and Matthaei (KLM) equivalent circuit model and spatial impulse response method by means of Field II software. These KLM model and Field II software are integrated, and a GA algorithm is used to optimize the design of the US transducer to obtain the best imaging performance. As a result, a 50-MHz single element probe is effectively optimized with 5 mm acoustic focal length, 72 $$\upmu {\text{m}}$$ μ m lateral, and 42 $$\upmu {\text{m}}$$ μ m axial imaging resolution, with an enhancement in imaging resolution over the conventionally designed and simulated probe by 10%. This work has the potential to benefit many applications that require a fast, high-resolution and strong US focus in skin imaging.

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