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This study thoroughly investigates the stability of a reconfigurable origami-inspired structure using the Finite Element Method (FEM). We use the Kresling pattern to design this foldable origami structure. We evaluate how the design’s geometric parameters, such as length ratio, number of polygon sides, and circumscribed circle’s radius, change the origami structure’s stability. We discover that the buckling load drops by increasing the structure’s length ratio. Furthermore, the results illustrate that the structure with less polygon side can be folded under less force. The circumscribed circle’s radius plays a significant role in mechanical responses to a tip force applied to an origami structure. Based on the results, it appears that the crease lines carry the greatest amount of tip load. The results and conclusions are analyzed to provide a complete design guide that can be used to improve origami structure performance.

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