Objective:To determine correlation of serum total testosterone with body mass index (BMI) and waist hip ratio (WHR) in healthy adult males.Methods:A cross sectional study was conducted on 200 nonsmoker healthy males (aged 30-50 years) university employees. They were selected by convenience sampling technique after a detailed medical history and clinical examination including BMI and Waist Hip Ratio (WHR) calculation. Blood sampling was carried out to measure serum total testosterone (TT) using facilities of Chemiluminescence assay (CLIA) technique in Dow Chemical Laboratory. Independent sample T test was used for mean comparisons of BMI and WHR in between low and normal testosterone groups. (Subjects having < 9.7 nmol/L of total testosterone in blood were placed in low testosterone group and subjects having ≥ 9.7 nmol/L of total testosterone in blood were placed in normal testosterone group). Correlation of testosterone with BMI and WHR was analyzed by Pearson Correlation.Results:Mean (± SD) age of the subjects included in this study was 38.7 (± 6.563) years mean (± SD) total testosterone was 15.92 (±6.322)nmol/L. The mean (± SD) BMI, and WHR were 24.95 (±3.828) kg/m2 and 0.946 (±0.0474) respectively. Statistically significant differences were observed in the mean values of BMI and WHR for the two groups of testosterone. Significant inverse correlation of serum total testosterone with BMI(r = -0.311, p = 0.000) was recorded in this study. However testosterone was not significantly correlated with waist/hip ratio.(r = -0.126, p = 0.076)Conclusion:Middle age men working at DUHS who have low level of serum total testosterone are more obese than individuals with normal total testosterone level.

Olive oil and sunflower oil (0.25 mu 100 g/day) orally produced significant decrease in serum cholesterol and triglyceride levels in cholesterol-fed rats. Sunflower oil initially increased cholesterol and triglyceride levels and then decreased them to below normal values whereas olive oil decreased them throughout the experimental period of one month. Serum cholesterol level in normal rats decreased during the first 10 days of sunflower oil treatment and then returned to normal values. Olive oil reduced the serum cholesterol upto 20 days of treatment and increased it significantly on 30th day of treatment. Myocardial triglyceride concentration increased after 1 week of olive oil administration but was normal after 2 weeks. Sunflower oil decreased the myocardial triglyceride after 1 week but increased it significantly after 2 weeks. Olive oil contains 8-10% poiyunsaturated fatty acid in comparison to 50-60% in sunflower oil. Therefore the hypolipidaemic action of olive oil is not due to its unsaturated fatty acid content alone. Olive oil seems to contain some factor(s) to produce this action. Saponification of 4 yielded the diol 5, M = 432, mp 199-201°C , which was easily oxidized to the ketone 6, M = 430, mp Abstract: The stereostructure of wuweizisu B, a dibenzocyclooc. tadiene lignan from the seeds of Schi.candra chinensis Baill, was established by partial synthesis and spectral analysis.

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