Introduction: The revelation of primary hyperparathyroidism by acute pancreatitis is an exceptional situation. Materiel and Methods: A case report. Case Report: We report the case of a 73 years old patient, hypertensive, having the antecedent of an ischemic cardiopathy complicated by cardiac insufficiency and atrial fibrillation, admitted to the urgencies for an abdominal pain evolving since 10 days, associated with vomiting, the initial biological assessment showed lipasemia at 2543IU/l, kidney failure and malignant hypercalcemia at 142mg/l. The etiological work-up showed primary hyperparathyroidism with double localization, the patient benefited from a parathyroidectomy with a good clinicobiological evolution. Discussion: The association hyperparathyroidism - acute pancreatitis was most often explained by the link of hypercalcemia, most of the above theories have not presented scientific evidence, and the current challenge is to seek a direct link between these two pathologies, the genetic theory remains an option, but its role is not clear.

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