Aim:To asses the effects of topical application of aqueous extract of either Propolis or Miswak on the post-operative outcomes in relation to the duration of operation after surgical removal of lower third molar was performed. Material and Methods: A total of 97 patients participated and distributed randomly into 3 groups according to the medicament applied into the extraction socket: Group I, in which 5% aqueous solution of propolis extract used; group II, in which 10% aqueous solution of Miswak extract used; and group III, in which distilled water used (control group). Results: A significant improvement in post-operative outcome at 3 rd day in both group I and II comparing to group III was observed. No significant difference noticed at 1 st day and 6 th day. Assessment of dry socket showed no significant difference in between the three study groups. However, when assessment performed in relation with operation time, a significant difference noticed in between the three study groups with high incidence of dry socket reported in operation take longer than 30 minutes in the three study groups. Conclusion: Aqueous extract of Miswak and Propolis as a topical medicament following lower third molar extraction had a slight reducing effect on the severity of post-operative complications.Al-Sultan FA, Mustafa LA, Al-Niaimi AI. Aqueous extracts of Propolis and Miswak as topical medicament to improve post-operative outcome after surgical removal of impacted lower third molar.