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Background The liver has an important role in the different metabolic processes. So, inborn errors of metabolism will result in several metabolic disorders, which can cause acute or chronic liver disease leading to cirrhosis and liver cancer. Main body In one of our Egyptian conferences, the United Conference of Hepatogastroenterology and Infectious Diseases (UCHID) 2022, our authors discussed the debates on the management of Wilson’s disease, hereditary hemochromatosis, and alpha one anti-trypsin deficiency. Conclusion The session summarized the pitfalls in the management of the 3 serious metabolic liver disorders with focused take-home messages to every physician.