Background: Aging, inflammation, oxidative stress, and metabolic syndrome are the main important factors in brainderived neurotrophic factor (BDNF) level. Aim: The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-curcumin on IL-6, IL-10 and BDNF in 60-65 year females with metabolic syndrome (MS). Materials and methods: Forty-four women with metabolic syndrome (Mets) voluntarily took part in the present study. Participants were randomly divided into 4 groups of MetS exercise + Nano-Curcumin (MENC), MetS exercise (ME), MetS Nano-Curcumin (MNC), MetS control (MC). During the first week, MENC and ME groups participated in three sets of 10-min aerobic exercise training (AT) with a treadmill with 5-min rest parts between the sets. One minute was added to the duration of exercise sets weekly. Blood samples were collected before and after 6 weeks. IL-6, IL-10 and BDNF levels were measured by ELISA method. To analyze the data, Paired-samples t-test with the significance level of (P ≤ 0.05). Results: IL-10 and BDNF concentrations significantly increased after a 6-week intervention (P ≤ 0.05). Also, IL-6 serum levels significantly decreased (P ≤ 0.05). Besides, the results of the present study suggested that nano-curcumin supplementation significantly decreases serum concentrations of malondialdehyde (MDA), and hs-CRP in subjects with metabolic syndrome. In addition, the results of the present study suggested that nano-curcumin supplementation significantly increases serum concentrations of BDNF, IL-10, and total antioxidant capacity (TAC) in subjects with metabolic syndrome. Conclusion: Findings show that both of the regular exercise and consumption of NanoCurcumin for 6 weeks reduce inflammation. Combination of these two leads to even more reduction of inflammation. The regular exercise led to a decrease at the fat percentage, which deceased IL-6 level and increased IL-10 level. So, this change led to increasing BDNF's levels.

Background:The aim of this research was to investigate the effect of eight-week aerobic exercise with moderate intensity and consumption of curcumin on TNF-α and Medium-term memory in 60-65 years old women with syndrome metabolic.Methods: 44 women with metabolic syndrome (MetS) voluntarily took part in the present study. Participants were randomly divided in 4 groups of MetS exercise+ Curcumin (MECU), MetS exercise (ME), MetS Curcumin (MCU), MetS control (MC). During the first week MECU group and ME participated in three sets of ten-minute aerobic exercise training with treadmill (AT) also they have 5 minute rest part between the sets. One minute was added to the duration of exercise sets weekly basis. Blood samples and memory test were conducted before and after eight -week. TNF-α level was measured by ELISA method and memory test were conduct with Picture recall test. To analyze the data, researcher made use of One-Way ANOVA, paired-sample t-test with the significance level of (P≤0.05).Results: After eight -week interventions TNF-α significantly decreased (P≤0.05). Also Medium-term memory significantly increased (P≤0.05). Conclusion:These findings indicate eight -week interventions induce to increase Medium-term memory and maybe this increasing relative to decreasing in TNF-α level and ameliorate in metabolic syndromes factors.

Backgrounds and ObjectivesThe use of anti-in ammatory supplements is important in improving the executive function of obese people. The aim of this research was to investigate the effect of 6 weeks of aerobic exercise with moderate intensity and consumption of nanocurcumin on IL1β, nitric oxide, and depression in women aged 60-65 with metabolic syndrome. Materials and Methods44 women with metabolic syndrome (MetS) were randomly selected and divided into four groups of 10, including MetS exercise+ Curcumin (MECU), MetS exercise (ME), MetS NanoCurcumin (MCU), MetS control (MC Training groups performed an exercise protocol of aerobic exercise for 6 weeks (three sessions per week). Blood samples were obtained before and after the training period for antioxidant indicators and lipid degradation measurement. Also, the Beck anxiety questionnaire was used for evaluating levels of anxiety. T-test and one-way analysis of variance were used for the evaluation of within-group and between-group differences, respectively. ResultsThere was a signi cant difference in IL1β, nitric oxide (NO), and depression before and after exercise in all three experimental groups (p≤0.05). Also, the results showed a signi cant difference in the level of NO and depression in the research groups. The highest decrease in these variables was observed in the aerobic training group and training with nanocurcumin consumption group (p≤0.05). ConclusionThese ndings indicated that six-week nanocurcumin supplementation with aerobic training is a suitable method for reducing IL1β and NO and depression, preventing metabolic, cardiovascular, and in ammatory diseases in women with metabolic syndrome.

BackgroundThe purpose of this study was to investigate the effect of 12 months of aerobic exercise combining stachys lavandulifolia (S. lavandulifolia) consumption on anxiety, Metabolic Syndrome profiles and antioxidant defense (Glutathione) and lipid peroxidation (Malondialdehyde) in 50-65 years old women with syndrome metabolic.Methods48 women with syndrome Metabolic were randomly divided into four groups: exercise (n=12), exercise+S. lavandulifolia (n=12), S. lavandulifolia (n=12) and control group (n=12). S. lavandulifolia groups consumed 3 g aerial parts of S. lavandulifolia daily. Training groups performed an exercise protocol of aerobic exercise for 12 months (three sessions per week). Blood samples were obtained before and after training period for antioxidant indicators and lipid degradation measurement. Also, Beck anxiety questionnaire used for evaluating levels of anxiety. T-test and one-way analysis of variance were used for the evaluation of within-group and between-group differences, respectively.ResultsA significant increase was observed in serum levels of Malondialdehyde (P =0.004), Catalase indexes (Pvalue= 0.01), and Glutathione (P=0.001) in the training group and S. lavandulifolia groups after 12 months. Body weight, BMI, and SBP and Anexiety was decreased significantly greater in exercise +S. lavandulifolia group compared to control, exercise and S. lavandulifolia groups (P=0.001)ConclusionAnxiolytic effect and Anti-Oxidative Stress Activity was seen, so taking S. lavandulifolia along with exercises may have beneficial effects on reinforcement the antioxidant system and prevention of anxiety and The negative effects of indicators related to cardiovascular disease in women with metabolic syndrome.

Background and purpose The aim of this research was to investigate the effect of twelve Month aerobic exercise whit moderate intensity on anxiety in 50-65 years old women with syndrome metabolic and relation between anxiety and Syndrome Metabolic profiles.Materials and methods 24 women with syndrome Metabolic participated voluntarily in this investigation and divided in two-group MetS exercise (ME), MetS control (MC). ME group participated in an aerobic exercise training (AT) program (12 Month), three session per week, each session contained three performing parts and two rest part. Also, Beck anxiety questionnaire and blood samples were conducted before and after training for evaluating levels of anxiety. Data were analyzed using Pried-sample T-Test, Independent samples T-Test, and Pearson correlation. Results anxiety after 12-month aerobic exercise significantly decreased (P˂0.05), and there was a significant relation between improvement of syndrome metabolic and decreasing of anexiety.Conclusion These findings indicate that 12-month aerobic exercises induce to decrease anxiety and ameliorate syndrome metabolic. Moreover, we can say ameliorating in Syndrome Metabolic profiles maybe related to decreasing in anxiety levels.