Türk derm-De ri Has ta lık la rı ve Fren gi Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. Turk derm-Arc hi ves of the Tur kish Der ma to logy and Ve ne ro logy, pub lis hed by Ga le nos Pub lis hing. ÖzetAmaç: Bu çalışmada renal transplant hastalarında görülen deri bulgularının sıklığı ve klinik özelliklerin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda renal transplantasyon yapılan 116 hastanın dosyaları retrospektif olarak incelendi. Altı aylık takip süreleri olan hastaların verileri değerlendirmeye alındı. Yaşları 10-68 arasında değişen (ortalama 36,62) 68 erkek (%58,6) ve 48 kadın (%41,4) hasta vardı. Hastaların detaylı dermatolojik muayeneleri yapıldı. Hastalar cinsiyet (erkek-kadın), transplantasyon süresi (1-5 yıl, 5-10 yıl ve 10 yıl üzeri), ve kullanılan ilaçlara (siklosporin, takrolimus, bu iki ilaç dışında immünosüpresan ilacı kullanan) göre gruplandırıldı. Bulgular: Transplant hastalarında en sık görülen deri bulguları infeksiyon hastalıklarıydı. Deri bulguları onikomikoz (13), tinea pedis (9), akneiform lezyon (15) ve verruka (9) şeklinde kaydedildi. Altı ay sonraki klinik değerlendirmede benzer sonuçlar elde edildi. Klinik muayenede hastalarda %7 premalin ve malin lezyon tespit edildi. Hasta gruplarına göre elde edilen sonuçlarda cinsiyet, transplantasyon süresi ve kullanılan ilaçların klinik bulguları etkilemediği belirlendi. Sum maryBackground and Design: This study is conducted to determine the prevalence and clinical characteristics of cutaneous manifestations in renal transplant patients. Materials and Methods: Hospital records of 116 renal transplant patients were retrospectively investigated. The data obtained from patients who had 6 months follow-up period were evaluated. There were 68 (58.6%) males and 48 (41.4%) females aged between 10 and 68 years (mean=36.6 years). Detailed dermatologic examination was performed. The patients were grouped according to gender (male-female), posttransplant period (1-5 years, 5-10 years, >10 years) and the drugs used (cyclosporin, tacrolimus, other than these two immunosuppressant drugs). Results: The most common cutaneous manifestations were infectious. The dermatological findings were onychomycosis (13), tinea pedis (9), acneiform disorders (15), and warts (9). The clinical evaluation after 6 months has also demonstrated the same result. Among the evaluated patients, 7% showed premalignant or malignant manifestations on clinical examination. According to the results obtained from the patient groups, it was found that gender, length of post-transplant period, and use of immunosuppressant drugs do not influence the clinical manifestations of patients. Conclusion: Dermatologic examinations and long-term follow-up should be performed in renal transplant patients. (Turkderm 2013; 47: 88-93)
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