Atherosclerosis, an underlying cause of cardiovascular disease, is responsible for around half of all deaths in the wide world. 1 Interferon gamma (IFN-γ) is a signature cytokine of Th1 cells that play a key role in the atherosclerosis process. 2 It has atheroma-promoting properties, and involved both in early and late stages of atherosclerosis by promoting the recruitment and activation of T cells and macrophages, leads to the production of proinflammatory cytokines. 3 Several immunohistochemical studies have discovered localization of IFN-γ in the atherosclerotic lesion. 4 Studies also report that the removal of IFN-γ or its receptors leads to a reduction in atherosclerosis. 5 Obesity is one of the vital risk factors for atherosclerosis and cardiometabolic syndrome. There is evidence that proinflammatory cytokine, including IFN-γ are overexpressed from adipose tissue. Various mechanisms have been suggested Background and objective: Coronary atherosclerosis is an inflammatory disease that may be caused by numerous factors. One of the most important factors is obesity; there are high concentrations of interferon gamma (IFN-γ) in obese patients. This study aimed to assess the levels of proinflammatory markers IFN-γ and high sensitive C-reactive protein (Hs-CRP) in obese coronary atherosclerotic patients and determine its correlation with lipid profiles. Methods: The present case-control study was carried out between December 2017 and May 2018 in the Cardiac Center-Surgical Specialty Hospital in Erbil city. It included 49 coronary atherosclerotic patients, 25 males and 24 females, and 39 controls. The sera were subjected to estimate of some inflammatory biomarkers including IFN-γ, Hs-CRP, and lipid profile such as total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoproteins cholesterol (LDL-C) and very low-density lipoproteins (VLDL-C). Results: Serum concentrations of IFN-γ and Hs-CRP in coronary atherosclerotic patients were increased significantly than controls (P = 0.031, P = 0.001), respectively. Indeed the same above results were seen in obese coronary atherosclerotic patients and controls than non-obese coronary atherosclerotic patients controls. The mean concentration of lipid profile in obese coronary atherosclerotic patients was decreased than non-obese coronary atherosclerotic patients and controls, with no significant differences (P ≥0.05). There was a weak negative significant correlation between IFN-γ and HDL-C in obese coronary atherosclerotic patients (r=-0.456; P = 0.040). Conclusion: Proinflammatory cytokine as IFN-γ played a vital role in the pathophysiology of obese atherosclerotic patients in combination with Hs-CRP and LDL-C, which could be used as predictors for progressive the disease.