The hemostatic alterations play an important role in malaria pathogenesis and in the progression of disease. In severe infection the accelerated coagulation cascade activity with accelerated fibrinogen turnover increase the bleeding tendency and may lead to DIC. The present study was aimed to determine the effect of malaria parasites on Prothrombin Time and Activated Partial Thromboplastin Time Levels. A single citrated blood sample of patients diagnosed with malaria was analysed in semi-automated coagulation analyzer at the time of presentation, the values were compared with healthy controls. Data was analyzed by mean standard deviation and by 't' test using SPSS software version 16. PT and APTT were significantly raised in cases when compared to control group, prolonged APTT is observed in 44% (P.value.001) and prolonged PT is observed in 43% of cases (P. value .016), the mean of PT (15.73 sec), and the mean of APTT (40.24 sec) in cases group. The mean of PT and APTT in control group, (13.94 sec), (30.87 sec) respectively. This study concluded that malaria infection altered the blood coagulation mechanism causing significant prolongation in PT and APTT.

college of medical laboratory science. 2. Sudan university of science and Technology, colleges of medical laboratory science.(Head department of clinical chemistry). 3. Sudan university of science and Technology, colleges of medical laboratory science.