Lithium is frequently used in the management of bipolar affective disorders. It has a narrow therapeutic index and can cause acute or chronic intoxication. Toxic symptoms may be present even when concentrations are within the recommended therapeutic range. We believe that lithium intoxication is a very important issue for a physician. In this report, we aimed to evaluate the pathophysiological view of two chronic lithium intoxication cases accompanied by hyponatremia.
Keywords: Hyponatremia, intoxication, lithiumLityum bipolar affektif bozuklukların tedavisinde sıklıkla kullanılır. Dar bir terapötik indeksi olan ilaç akut yada kronik zehirlenmeye neden olabilir. Zehirlenme semptomları ilaç önerilen terapötik konsantrasyonda olsa bile ortaya çıkabilmektedir. Biz lityum zehirlenmesinin doktorlar açısından çok önemli bir konu olduğunu düşünmekteyiz. Bu bildiride hiponatremiyle seyreden iki kronik lityum zehirlenmesi olgusunu patofizyolojik açıdan değerlendirmeyi amaçladık.Anahtar kelimeler: Hiponatremi, lityum, zehirlenme Abstract / Öz
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