Background: NADH and NADPH are critically important but labile coenzymes. Results: We identified an enzymatic repair system for hydrated NAD(P)H consisting of an ATP-or ADP-dependent dehydratase and an epimerase. Conclusion: The extreme conservation of this repair system suggests its importance for many species. Significance: This work indicates that searches for other enzymes involved in metabolite and coenzyme repair might be fruitful.
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