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This study examined religiosity and adolescent depression through a retrospective analysis viadata from the 2012 National Survey on Drug Use and Health. A national sample of adolescents aged12-17 years (n = 17,399) served as the participants of this study. Demographic characteristics were deter-mined by conducting frequency distributions. Odds ratios were computed to determine whether past year(2012) MDE differed based on adolescent involvement in religiosity. Multivariable logistic regressionanalyses were computed to examine whether past year MDE differed based on adolescent involvement inreligiosity for males and for females. Findings indicated that 9.7% of adolescents had a Major DepressiveEpisode (MDE) within the past year. Males at highest risk were those who did not feel their religious be-liefs were an important part of their life or that it was important their friends share their religious beliefs.Females at highest risk were those who did not feel their religious beliefs influence their decisions or thatit was important that their friends share their religious beliefs. Such findings may indicate that certainaspects of religious involvement may provide protective effects against adolescent MDE.

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