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Major causes of olfactory disorders are sinonasal disease, viral upper respiratory tract infection, head trauma and old age. Olfactory testing is an important part of objective assesment of the severity of the disease in chronic rhinosinusitis and nasal polyposis. The aim of this study was to correlate results of objective smell testing with subjective scores on olfaction and other nasal symptoms in different subgroups of patients with smell impairment.Data were extracted from questionnaires filled by patients sent to smell testing by the ENT specialist. For the analysis data were divided in subgroups: 20 with chronic rhinosinusitis (CRS), 24 patients operated for nasal polyps, 7 patients with nasal polyps on medical treatment, 7 with hyposmia after common cold, 4 with anosmia and 11 controls with no smell impairment. Smell testing was done by using the Sniffin Sticks 12 complete odorant. This test is based on the assessment of odor identification abilities for 12 standard odors with forced choice. Subjective scores on (0-4) were taken for olfaction, nasal obstruction, hypersecretion and headache.The correlation between subjective score for olfaction and olfactometry score was significant for the whole group (r 0.682), and was similar when anosmic and controls were excluded. Subjective olfaction and olfactometry score did not correlate with any other symptom. Comparing correlation coefficients between the subgroups, it seems that patients with CRS and nonoperated nasal polyp patients have better correlation between subjective and objective smell assesment than patients operated for nasal polyps and those who had olfactory lesion following viral infection.Although correlation between subjective and objective smell assesment is significant, some subgroups of patients overrate their ability to recognize odors. STRESS EFFECTS ON ALLERGIC INFLAMMATION OF THE AIRWAYS Pontus Stierna and Susanna GeorenDepartment of Otorhinolaryngology, Karolinska University Hospital, Stockholm, SwedenWe have used a mouse model to investigate the effects of endogenous GC synthesis and GC receptor inhibition, as well as acute stress, and different doses of exogenous administered GCs on inflammatory cells in different cellular compartments in allergic airway inflammation. including nerve growth factor (NGF) in the airways, during allergic inflammation.First we investigated the effects of endogenous GCs on eosinophilic airway inflammation. Inhibition of GC release with metyrapone (ME) induced an increase of bone marrow eosinophilia and when the ME treatment was combined with a GC receptor antagonist (RU 486) the allergen-induced bone marrow eosinophilia was further enhanced.The second study was focused on the effects of timing of a short acute stress on allergic airway inflammation in upper and lower airways. Short stress applied before an allergen challenge decreased the allergen-induced eosinophilia in bronchoalveolar lavage fluid and lungs and also the inflammation in the nasal tissue. No effects on eosinophilia or inflammation were seen...

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Irregular growth in the surrounding lands is one of the most important issues for the city managers and programmers at various levels. Whereas nowadays study the process of land use changes to urban use plays the main role in long time decisions and programs, predicting the process of city growth and its modeling in future with precise methods for management and urban expansion control will be necessary more than other times. One of urban growth modeling is cellular automata model. This model has been used widely in urban studies because of its dynamic nature, ability of Integration with other models, ability to modify the model and required data availability. In this article, to maximize the efficiency of the cellular automata model and its constraints, the integration of the AHP automated cell model and cellular automata model have been used; and its accuracy has been evaluated. This article has been practical because its related principles has been collected in a documentary manner and has been used to analyses the issue in comparative and quantitative methods. Initially, the unplanned growth of Qazvin city has been investigated by Holdern and Shannon model. Then main parameters including distance from roads, land prices, distance from faults, distance from the rivers, soil gender, slope, permission to build land, topography, landscape, view to gardens and forest park as parameters involved in the development of Qazvin city are considered. The input data used in this research are Landsat tm and DEM images of the city of Qazvin in 1996 and 2016. Also, to evaluate the correctness of the model responses, the map of the developed regions in 2016 and the Kappa coefficient have been used. The Kappa coefficient is 92.3%, which is considered significant and appropriate and gave the fact that the Kappa number is acceptable. The Qazvin simulation was made in 2026. The results show that the proposed integrated model is suitable for studying urban growth.