Heart failure is the most common cardiovascular disease and its prevalence and incidence increase as the age goes up. This chronic situation affects the quality of life of patients and their family. The main objective of this study was to determine quality of life of elderly patients with heart failure. A cross-sectional study conducted among 150 patients with heart failure aged 50 and above who entered cardiovascular clinic and Coronary Care Unit (CCU) ward of Vali-Asr hospital of Fasa, Iran, from March to August 2013. Patients with a left ventricular ejection fraction below 50% entered. WHOQOL-BREF questionnaire was used to evaluate the quality of life of patients. All the statistical analyses were performed using the statistical package for social sciences version 16.0. Overall we enrolled 147 patients including 77 (52.3 %) males and 70 (47.7 %) females with the mean age ± standard deviation of 63±27 years. There was not any signifi cant relationship between NYHA class, ejection fraction, past medical history of hypertension, diabetes mellitus, chronic obstructive pulmonary disease, renal failure, pulmonary hypertension in patients and variables of our questionnaire. Social and environmental aspects were the highest and lowest scores of this questionnaire, respectively (53.85 ±21.28 and 45.74 ±17.67). There was not any correlation between job of patients and any aspect of their quality of life (p-value = 0.49 for total).Our results indicated that the majority of heart failure patients had poor and undesirable quality of life and the women have weaker scores of quality of life variations than men. Therefore, controlling some available variables among these patients is suggested.