Ehrlichiosis is a zoonosis, transmitted by ticks, of unknown incidence in Colombia, with a wide spectrum of clinical manifestations, remarkably similar to those that occur in other infections, which makes its diagnosis difficult. We present the case of a girl with fever, headache, nausea, generalized rash, epistaxis, thrombocytopenia, leukopenia, and meningitis, in whom ehrlichiosis was confirmed through polymerase chain reaction (PCR) in whole blood. The clinical suspicion based on the symptoms and the history of contact with ticks and sick dogs were key to the initiation of early empirical treatment and allowed the patient to heal. The description of this case aims to make this disease more visible to avoid delays in diagnosis and treatment that can lead to adverse outcomes, including death.