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Objective:The objective of the study was to analyze the sociodemographic, clinical, and laboratory factors that can increase mortality from chronic kidney disease (CKD) in susceptible older adults (≥ 60 years). Material and methods: This study is a retrospective case-control study. The characteristics of surviving patients and mortality early or 90 days after hospital stay were compared. Results: One hundred and eight patients with CKD were included. About 29.6% died less than 90 days after hospital admission; 70.4% were survivors. The most frequent comorbidities found were diabetes (90.7%) and hypertension (88%). The logistic regression showed early death risk variables, such as stay in the intensive care unit (ICU) (odds ratio = 19.25; p = 0.008). Conclusions: Early mortality was 29.6%. The main risk factors were ICU stay. The main cause of death was septic shock.