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Background: Interprofessional education is essential to ensure that health care graduates are prepared for collaborative practice. One way to prepare students for interprofessional practice is to expose them to interprofessional activities throughout their educational program. Method: In this article, we present the design and curricular implementation of an interprofessional health care escape room—a type of serious game in which teams of interprofessional participants were provided with a fictitious case. The participants were given 1 hour to work together to solve puzzles and create a postdischarge care plan for the patient. Results: Seven hundred eighty-six students, across four professions, have participated in this experience as part of an academic course. The results were positive: 89.5% of participants found that the activity improved communication and teamwork, and 94.1% felt that team members were listened to. Conclusion: This report demonstrates the value of an interactive interprofessional activity for advanced learners. [ J Nurs Educ . 2020;59(1):46–50.]