Introduction: Management of stag horn calculi still being real challenge for urologists dedicated to stone management. Nowadays it is difficult to obtain a free stone rate with a single procedure in these complex cases even with the recent advances in endourology. The aim of this study is to present our results and review of published case series in PubMed. Patients and method:We reported our experience in laparoscopic anatrophic nephrolithotomy in 8 patients with stag horn calculi diagnosis between 2014-2015. We evaluated patient variables like age, stone size, surgical time, blood loss, transfusion, complications, hospitalization days and free stone rate. And we performed a comparison with previous case series published. It is worth highlighting that the same surgeon performed all surgeries.Results: A total of 8 patients undergo to laparoscopic anatrophic nephrolithotomy, patients mean age was 42.1 years, stone size 52.63mm, surgical time 127.5 min, warm ischemia 29.5 minutes, blood loss 218.7 ml, transfusion rates 0%, complications 25%, hospitalization days 3.5 days and stone free rate was 75%. Conclusion:Laparoscopic anatrophic nephrolithotomy could be a feasible option in high volume centers to patients with complex renal stones that will require multiple percutaneous and endourologic procedures, or those who are no candidates to percutaneous nephrolithotomy. Achieving laparoscopic anamorphic nephrolithotomy a reasonably stone free rate with one procedure.