Adsorption and thermal desorption dynamics of acetone in fixed bed silica gel were studied experimentally and theoretically. The effect of process factors on adsorption and desorption performances was established. Acetone adsorption from air stream was performed by the dynamic (flowing gas) method in a laboratory set-up at two levels of air superficial velocity (0.7 and 1.7 cm/s), temperature (30 and 40 °C) and adsorbent particle diameter (0.21 and 0.54 cm). The values of saturation adsorption capacity (0.147-0.270 g/g) increased up to 78 % and 36 %, respectively, with a decrease in air velocity and adsorption temperature. Acetone thermal desorption from spent silica gel was studied in a thermobalance at three levels of process temperature (60, 70 and 80 °C) and two values of particle size (0.21 and 0.54 cm). Equilibrium desorption efficiency (63-81 %) was up to 14 % larger for finer particles and increased with the desorption temperature. Kinetic models with relevant parameters adjusted based on experimental data were adopted to predict the dynamics of acetone adsorption and thermal desorption. The models simulated well the real conditions and could be applied to scale up and operate the adsorption columns used for air remediation.