Sex differences in various epidemiological features of psychiatric diseases may have both sociological and biological etiologies.General and psychiatric drugs demonstrate sexually dimorphic pharmacokinetics and pharmacodynamics. Research on sex differences in disease mechanisms and drug therapies is necessary.Brain transcriptome profiling has revealed many sex-and diseasespecific expression patterns. These include regulatory pathways in major depressive disorder, bipolar disorder, and schizophrenia.Brain long noncoding RNA (lncRNA) expression patterns are often sex-biased.lncRNAs are prominent at the interface between psychiatric and neurodegenerative disease, such as in the case of NEAT1. lncRNA expression is often affected by drugs. Pharmacotranscriptomic aspects of common drugs may have a sex-specific role involving lncRNA expression. Further study is needed in this developing field.