ÖZET Akut izoniazid intoksikasyonu: konvülziyon, koma ve asidozun nadir bir nedeni

Objective: Tracheostomy is one of the most common invasive procedures in emergency rooms, intensive care units, and the bedside. In the intensive care unit, tracheostomies are most often used for prolonged mechanical ventilation, to preserve the airway and to permit pulmonary drainage. Percutaneous dilatational tracheostomy (PDT) was performed using the Seldinger method. To minimize tracheal posterior wall damage, bronchoscopy guidance was used to determine the proper spot for tracheal puncture, guide real-time needle entry into the trachea, and confirm cannula position. This study introduces bronchoscopyguided modified mini-surgical PDT and aims to evaluate early complications with 388 case analyses. Methods: Demographic data from patients, intensive care indications, APACHE-2 scores, duration of stay on the ventilator before tracheostomy, total duration of stay, and early complications during tracheostomy were recorded by analyzing patient files. All data from PDT patients between 2018 and 2022 were retrospectively reviewed. Results: Of 492 tracheostomies, 388 (78.8%) were opened percutaneously. The mean and median duration of stay on the ventilator before tracheostomy were 12.95 and 12 days, respectively. The mean and median duration lengths of stay were 29.43 and 14.355 days, respectively. The most common indication for tracheostomy was chronic obstructive pulmonary disease in 70 (18%), patients. Complications related to tracheostomy were observed in 19 patients, representing a complication rate of 4.9%. Of these, 2 (0.5%) bleeds stopped with cautery, and 2 (0.5%) bronchospasms occurred during the procedure. Conclusion: Percutaneous dilatational tracheostomy is a simple and safe tracheostomy method. Its use with bronchoscopy can facilitate the procedure and minimize the complications that may occur.

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Situs inversus totalis is a congenital syndrome, in which all the internal organs are in the opposite position, including dextrokardia. Most patients are asymptomatic and maintain their normal life. Kartagener syndrome may accompany situs inversus totalis. Diagnosis may be overlooked in patients with situs inversus totalis in emergency situations. Patients with this syndrome should inform the clinician as this will facilitate the diagnosis. Acute appendicitis is an emergency situation that would require urgent intervention. Appendicitis symptoms can be observed in the left lower quadrant of patients. We present a case concerning the anaesthetic management of a patient with situs inversus undergoing an emergency appendectomy.

What Is Known and Objective: Acute kidney injury (AKI) is a disorder that is commonly seen in patients in the intensive care unit (ICU) and has a detrimental impact on the patients' clinical prognosis. Although a variety of factors contribute to the development of AKI in patients, drug-induced AKI is a common occurrence in the ICU. With the widespread availability of clinical pharmacy services, the clinical pharmacist's consultation service to the healthcare team aids in the resolution of drugrelated issues and the enhancement of therapeutic outcomes. The involvement of a clinical pharmacist in the ICU team is expected to minimize the incidence of druginduced AKI and enhance therapeutic results. Therefore, the goal of our study was to demonstrate the impact of having a clinical pharmacist on the occurrence, stages, and treatment of AKI. Methods: The study included two patient groups: intervention (n = 75) (IG) and control (n = 75) (CG) groups. The clinical pharmacist has made recommendations to the ICU team regarding the treatment of IG patients on drug selection, drug administration routes, drug dose adjustment, drug-drug interactions, drug-food or nutritional solution interactions, drug side effect management, and drug incompatibility. No interventions were provided by the clinical pharmacist in the CG patients. The clinical pharmacist visited patients regularly and noted the laboratory findings and pharmacological treatments of patients in the study groups on the patient follow-up forms.The obtained data of IG and CG were compared and statistical methods were used to assess them.Results and Discussion: According to our findings, AKI was found to be more common in CG than in IG (p < 0.05). Stage 1 was shown to be the most common AKI stage in the patients (p > 0.05). The gap between the patients' highest Cr and basal sCr values was less in IG (p < 0.05). When the association between reasons for ICU admission and AKI was investigated, pulmonary edema and acute respiratory failure were found to have a significant and positive relationship with AKI (p < 0.05). Furthermore, it was shown that patients with diabetes and cancer comorbidities were the most vulnerable to developing AKI (p < 0.05). Antibiotics, anaesthetics, and cardiovascular system medication categories were found to have a significant and positive correlation with AKI in patients (p < 0.05). Also, it was revealed that the usage of vancomycin, colistin, ampicillin-sulbactam, clarithromycin, ceftriaxone, midazolam, and dexketoprofen caused AKI (p < 0.05).