The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs i.e. peptides. Colon targeted drug delivery system (CDDS) is an Promising tool for treatment of inflammatory bowel diseases such as ulcerative colitis, crohn's disease, colon cancer, amobebiasis by both systemic and topical delivery of dug. This article review a detailed study about disease of colon, diagnosis of diseases of colon, anatomy of colon, factors affecting drug absorption and different approaches of colon including some current approaches like Pulsinicap system, Port system, Probiotic approach, Chronotropic system, Colal-pred system, Enterion capsule Technology Muliparticulate system and some past studies on colon drug delivery with evaluation method for site specific drug delivery to colon.