In drilling wells of two sections with a low angle in Tiputini Field-Block 43, have been implemented several hole cleaning practices, handling of different drilling parameters and drilling fluid properties in order to get an optimal hole cleaning. This study pretends to determinate and propose the operational ranges of each parameter involved in drilling and hole cleaning through statistical analysis using the main variables that participate during the drilling and cuttings transport in the intermediate section of 12¼" in the next wells with similar characteristic. For the variable selection that will use in the statistic study, it was considered three operational aspects: drilling, drilling fluid and hole cleaning. By means of statistic analysis was determined a regression model that fits the data and describe its behavior. In addition, it was made comparative graphs with each variable, determining the effect of drilling time in each formation. It was statistically determined that the drilling parameters that have the greatest influence in hole cleaning are the gallonage and ROP which will help to optimize the drilling operation of new wells.