Introduction/Background Ulcerative colitis, as well as intestinal inflammatory diseases in general is associated with a higher incidence of neoplasms, both due to the chronic inflammatory process and to many of the drugs used. Emphasize colon adenocarcinoma, cholangiocarcinoma (associated with PBC), lymphomas or skin cancer. The lymphoma of the primary gastrointestinal tract (LGIP) describes the lymphoma that originates in the gastrointestinal tract, representing only 5-10% of all lymphomas 1-3 and up to 20% of extranodal lymphomas 4,5. This type of lymphoma, however, is infrequent, constituting only 1-4% of gastrointestinal neoplasms5. Studies have suggested that the incidence of LGIP has increased, 4,7 a trend that could be explained by the presence of immunosuppression states, whether mediated by an acquired immunodeficiency syndrome (AIDS), by drugs in the context of a post-transplant or associated with diseases autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus or celiac disease. 4,8,9 Among the drugs that favor the development of lymphoma, thiopurine (azathioprine and 6-mercaptopurine) 10,11 and, to a lesser extent, anti-TNF biological therapy. 11