The pandemic SARS coronavirus 2 utilizes efficient mechanisms to establish infection and evade the immune system. Established infection leads to severe inflammation in susceptible patients, the main hallmark of progression to severe coronavirus disease (COVID-19). Knowledge of the mechanisms of disease has expanded rapidly. As inflammation emerges as the central pathophysiological feature in COVID-19, elucidating how the immune system, lungs and gut communicate and interact with microbial components of the ecological niches that conform the human microbiome will shed light on how inflammation and disease progression are promoted. Studying the microbiome in COVID-19 could allow scientists to identify novel approaches to prevent severe inflammation by targeting components of the human microbiome. Innovation in the aforementioned is needed to combat this pandemic.

We analyzed a single case of a patient with active Systemic Lupus Erythematosus (SLE), transplanted with Intestinal Microbiota (IMT). She had 34 years old, with active SLE with 9 years of evolution. She has lupic glomerulonephritis and the last 6 months diarrhea, the she loss weight (28kg) and had desnutrition (BCI 16). Treated with racecadotrilo and loperamide. A coprologic study showed Blastocystis hominis. She did not received treatment for this parasite. An IMT was done 9 months ago, reducing diarrhea and anxiety. After a week she was hospitalized because diarrhea, deshydratation. Under care of a nephrologist who prescribe Mycophenolic acid, and nothing change. A different nephrologist stops Mycophenolic acid and prescribe Azathioprine resulting in improvement when nausea and diarrhea ceased. Next day she was eating and recovered 7kg, however, she was anemic (her hemoglobin was 8g/dL) and she was transfused with total blood. Weights 15 more kilograms, oscillating between 52 to 55kg and her was asymptomatic. 55k. She offered testimony of her improvement. https://goo.gl/oHZeUT

We carry out a review of the world literature, regarding the role played by the Intestinal Microbiota (IM), -when transplanted- in the decrease and disappearance of diarrhoea, in many conditions. Some acute and most chronic. Also, we show our little experience regarding the effect of Intestinal Microbiota Transplant (IMT), also known as Fecal Microbiota Transplant (FMT). We refer how patients with Irritable Bowel Syndrome, Diarrhoea variety, Anxiety, Systemic Lupus Erythematosus, Pseudomembranous Colitis, Intestinal Malabsorption Syndrome, Amyotrophic Lateral Sclerosis and Retroperitoneal Cancer operated on 4 occasions, secondary to left seminoma and right testicular teratoma (excised). We show that in all of them, the diarrhoea was reduced substantially and that the complications that appeared were minimal; without relevance or significant effect.

Chronic Kidney Disease (CKD) is associated with intestinal dysbiosis, especially when it is accompanied by arterial hypertension, metabolic disorder, sympathetic activation, and/or immune deregulation. One particularly common mechanism of pathogenesis triggered by dysbiosis is chronic inflammation. Recent research has highlighted the importance of the microbiota and its genes in health and disease. The aim of the current contribution is to review the possible advantages of certain innovative strategies for establishing eubiosis in CKD patients. A key advance in microbiota research took place in 2007 with the characterization of the human microbiome, finding billions of bacteria in the large intestine, which is 150cm long and has a surface area of 1.3m 2 . Such bacteria are mainly of the phyla Bacteroidetes and Firmicutes. According to the review of the literature, the use of probiotics, prebiotics, synbiotics, postbiotics, parabiotics, and intestinal microbiota transplantation can be beneficial for CKD patients under certain conditions. When intestinal microbiota transplantation afforded a positive outcome for a patient with a C. difficile infection, the procedure was provided with greater validity because this infection is a frequent complication in CKD patients. Upon performing any procedure for reestablishing eubiosis, the recommendations of the U.S. FDA in regard to the crisis of COVID-19 must be considered.

Male, 47 years old. For 26 years, he has a lack of extension and elevation of the right thumb. It extended to the whole hand, carpus and forearm. When he was child a vehicle hit his head, at the right temporal level, he did not lose consciousness. He practiced Extreme Soccer 2-3 hours a day. From 10 to 15 years old. In 1987 spider bite on the right leg. He made black process, of 10 centimetres that it took to heal. In 1998, with the problem he worked at 4 thousand meters high. The disorder did not advance. In 2000, car accident. In 2004, diminution of the strength in the left ankle. One year later the right. He cannot stand on tiptoes. Contracture in the legs, as well as the right arm. Pain in cervical 7 th , when bending over and incorporating the neck. Two Magnetic Resonances, with probable cervical hernia, small. Electromyography, normal. Genetic studies, No. HIV negative. Leukaemia of T lymphocytes in humans. Polio and West Nile virus not performed. Thereafter they treated him with ampules of Complex B, intramuscularly, daily and the process did not progress. Apitherapy once a week (60 bee stings), removing the sting. Lost weight on their forearms and ankles. It does pedal and cycling.On physical examination, only lack of hyperextension in fingers of the right hand, as well as of the carpus on the same side. Standing tends to fall. He cannot stop spiking and get dizzy. The fingers of the right hand are hypotrophic. Frequent contractures in both legs. He has never taken medication. Regarding ELA, after 12 months of evolution Intestinal Microbiota Transplantation (IMT), comments on the following: