Islam has comprehensive rule that regulate in all aspects of human life, including evireonmental issues. One fact of global problems related to environment is waste management problem. Zero waste is waste management system which it could be a holistic solution due to waste issue. This study aim to analyse the zero waste concept within Islamic-science prespective on municipal waste reduction as a solution to prevent environmental damage. This study use literature reviews method that focuse on waste management programs in Surabaya City which have been stated on a national and international scale. The results of this study show implementation of waste management programs In Surabaya City such as the depletion of disposable plastic usage, the existence of waste bank units, until the presence of a solid waste power plant infrastructure. However, the program implementation has not been able to decrease the number of resource in Surabaya landfill. It is because of poorly coordination between government and society, and the lack of environmental awareness about the harm of waste resource to environmental health. Thus, the existence of zero waste concept combined with Islamic-science prespective could lead direction movement to appreciate the importance of proper and correct waste management. Based on these results, it conclude that waste management with zero waste concept considered to become a new lifestyle in waste management namely Islamic lifestyle, because it is in line with Islamic law. Moreover, this new lifestyle could be implemented in all communities regarding to the nature is a gift form Allah SWT and humans have a command to protect it.

BACKGROUND: Bone fracture is the main consequence of osteoporosis, which may become a neglected disease. OBJECTIVE: This study aims to fabricate bovine hydroxyapatite-gelatine (BHA-GEL) based bone-implant with alendronate (ALE) in vivo. METHODS: Wistar rats were used for an osteoporotic animal model induced by ovariectomy. There were three groups: negative control, BHA-GEL implant, and BHA-GEL-ALE implant. Each group performed a defect by drilling the femur (diameter of 2.2 mm and depth of 2 mm). Observations on the closure of bone defects were performed by X-ray radiography at the second and sixth week after surgery. The mechanism of bone healing was observed by using hematoxylin-eosin (HE) staining and immunohistochemical technique with anti-vascular endothelial growth factor (VEGF) and anti-alkaline phosphatase (ALP) antibodies. RESULTS: The radiograph examination showed the implanted group had accelerated bone growth. In addition, the osteoblast, osteoclast and osteocyte had accelerated migration to the defect area. Moreover, the immunoreactive score (IRS) of VEGF at the sixth week in the BHA-GEL-ALE group was lower than the other groups. Meanwhile, the IRS of ALP in BHA-GEL-ALE was higher compared to other groups. CONCLUSION: The BHA-GEL-ALE implant accelerates the healing of bone defect in the osteoporotic rat by increasing the ALP expression and the total number of cells.