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An iodinated albumin solution was instilled into the isolated perfused dog lung through a bronchial catheter. During the 5-hr period following instillation, 6.4% of the iodinated albumin dose was absorbed from the lung into the pulmonary perfusion blood. Fifty-seven percent of the absorbed radioactivity passed through an Amberlite resin column indicating that absorption occurred as large protein molecules. Fractionation of the plasma protein-bound radioactivity on a diethylaminoethyl-cellulose column demonstrated that absorption of the iodinated albumin from the lung had been predominantly as intact albumin molecules. Since the pulmonary lymphatic drainage was interrupted in the perfused lung, absorption of the albumin must have been directly from the alveoli into the pulmonary capillary blood. It is concluded that in the isolated lung the primary mechanism for removal of albumin from the pulmonary alveoli is slow absorption of intact albumin directly into the pulmonary blood.

Although it is generally accepted that insulin accelerates the removal of glucose from the blood (1, 2), there has been disagreement regarding the effect of epinephrine on glucose utilization in normal individuals (2-5). The effect of hyperthyroidism on glucose tolerance tests has been found to be variable. The present study was undertaken to clarify the effects of epinephrine, insulin, and hyperthyroidism on the rate of removal of glucose from the blood of adult subjects by means of the rapid intravenous glucose tolerance test (6). MATERIAL AND METHODSAll subjects had been on a diet containing at least 150 grams of carbohydrate daily for at least one week. The rapid intravenous glucose tolerance test was carried out after a 14 hour fast, and the rate of glucose disappearance from the blood was determined as described in a previous publication (6). By this method the range of blood glucose disappearance rates in normal individuals is from 3.00 to 4.84 per cent per minute.A group of 21 normal males was employed in studying the effect of insulin and of epinephrine. A control test was performed on each subject. The test was performed in 17 of the group, 30 minutes following the subcutaneous administration of 0.5 mg. epinephrine. In a normal individual epinephrine produces a rise in the blood sugar which reaches a maximum within 25 minutes, following which there is a relative plateau for approximately 90 minutes corroborating previous work. In 18 of the group the test was performed immediately after the intravenous administration of 4 units of crystalline insulin. A time interval of approximately one month was allowed to elapse between tests in each subject.Seventeen patients with uncomplicated hyperthyroidism were studied before treatment with radioactive iodine, and the studies were repeated when a remission of the hyper-