There is no agreed management for Erectile Dysfunction (ED) for male patients with Diabetes Mellitus (DM). Regular Physical Exercise (PE) starts to be a more exciting area that needs further focus. This review attempts to gather available data about the ED burden, etiology, risk factors, assessment, and management. Further, it highlights the available evidence on the effect of PE on the progression of ED and the possible underline mechanisms. The available evidence is hugely supportive of the beneficial role of PE in the ED. The cardiovascular, neurological, endothelial, metabolic, and overall health benefits of PE are repeated mechanisms reported by many researchers. The possible explanation is quite not clear due to the complexity and bidirectional effect on many aspects related to the changes during PE. Further interventional studies are needed to determine the superiority of each factor. All physicians managing DM and ED are strongly invited to involve PE as part of their management plan in conjunction with other available treatment options. Research has to look after which type, duration, frequency, and intensity of PE is sufficient for detectable improvement in ED.

Th e World Health Organization (WHO) reported global increase in the prevalence of DM among adults from (4.7%) during (1980) to (8.5%) in (2014). Th is increase is more profound in low and middleincome countries. Th ere is gradual international increase owing to