In the legal field, victims and offenders frequently lie to avoid talking about serious incidents, such as past experiences of sexual abuse or criminal involvement. Although these individuals may initially lie about an experienced event, oftentimes these same people eventually abandon their lies and are forthcoming with what truly happened. To date, it is unclear whether such lying affects later statements about one's memory for the experienced event. The impetus of the present review is to compile the current state of knowledge on the effects of lying on memory. Based on existing literature, we will describe how deceptive strategies (e.g., false denials) regarding what is remembered may affect memory in consequential ways, such as forgetting of details, falsely remembering features that were not present, or a combination of both. It will be argued that the current literature suggests that mnemonic outcome is contingent on the type of lie and we will propose a theoretical framework outlining which forms of lying likely result in certain memory outcomes. Potential avenues of future research also will be discussed.

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Thyroid cancer is frequently difficult to diagnose due to an overlap of cytologic features between malignant and benign nodules. This overlap leads to unnecessary removal of the thyroid in patients without cancer. While providing some improvement over cytopathologic diagnostics, molecular methods frequently fail to provide a correct diagnosis for thyroid nodules. These approaches are based on the difference between cancer and adjacent thyroid tissue and assume that adjacent tissues are the same as benign nodules. However, in contrast to adjacent tissues, benign thyroid nodules can contain genetic alterations that can be found in cancer. For the development of a new molecular diagnostic test for thyroid cancer, we evaluated DNA methylation in 109 thyroid tissues by using genome-wide single-base resolution DNA methylation analysis. The test was validated in a retrospective cohort containing 65 thyroid nodules. By conducting reduced representation bisulfite sequencing in 109 thyroid specimens, we found significant differences between adjacent tissue, benign nodules, and cancer. These tissue-specific signatures are strongly linked to active enhancers and cancer-associated genes. Based on these signatures, we developed a new epigenetic approach for thyroid diagnostics. According to the validation cohort, our test has an estimated specificity of 97% [95% confidence interval (CI), 81-100], sensitivity of 100% (95% CI, 87-100), positive predictive value of 97% (95% CI, 83-100), and negative predictive value of 100% (95% CI, 86-100). These data show that epigenetic testing can provide outstanding diagnostic accuracy for thyroid nodules.

Purpose. There is major disagreement about the existence of individual differences in deception detection or naturally gifted detection ‘wizards’ (see O'Sullivan & Ekman, 2004 vs. Bond & Uysal, 2007). This study aimed to elucidate the role of a specific, and seemingly relevant individual difference – emotional intelligence (EI) and its subcomponents – in detecting high‐stakes, emotional deception. Methods. Participants (N= 116) viewed a sample of 20 international videos of individuals emotionally pleading for the safe return of their missing family member, half of whom were responsible for the missing person's disappearance/murder. Participants judged whether the pleas were honest or deceptive, provided confidence ratings, reported the cues they utilized, and rated their emotional response to each plea. Results. EI was associated with overconfidence in assessing the sincerity of the pleas and greater self‐reported sympathetic feelings to deceptive targets (enhanced gullibility). Although total EI was not associated with discrimination of truths and lies, the ability to perceive and express emotion (a component of EI), specifically, was negatively related to detecting deceptive targets (lower sensitivity [d′]). Combined, these patterns contributed negatively to the ability to spot emotional lies. Conclusions. These findings collectively suggest that features of EI, and subsequent decision‐making processes, paradoxically may impair one's ability to detect deceit.