Background: Adrenal haemorrhage (AH) in the new-born is not that uncommon and has been reported frequently. AH occurs most often after a traumatic delivery or complicated neonatal course. Design and setting: A retrospective, hospital-based study conducted at king Khalid university hospital (KKUH), endocrine service, Riyadh, Saudi Arabia, during the period January 2014 and July 2018. Methods: Medical records of neonates who had been diagnosed to have AH were reviewed. Data included age, sex, clinical manifestations, laboratory and radiological investigations. Results: During the period under review, five neonates were diagnosed to have adrenal haemorrhage. All were term male infants, who were delivered vaginally .one baby was large for gestational age (LGA), and three babies had perinatal hypoxemia. Clinical symptoms were not specific and diagnosis was confirmed by performing abdominal sonography (USG). Conclusion: AH should be recognised in the new-borns with nonspecific symptoms who had potential risk factors. Abdominal ultrasonography (USG) should be performed to diagnose AH, and monitor its progress. Adrenal hormone testing also should be performed.
Background: Congenital adrenal hyperplasia (CAH) consists of a family of defects in the synthesis of steroid hormone in the adrenal cortex which results in high androgen levels. The androgen excess is present from early embryogenesis and results in varying degrees of virilization of the external genitalia. It can lead to major medical and psycho-social consequences. Design and setting: Eight Saudi adolescent and young women whose age ranged between 15 to 25 y with variable severity of CAH were studied to determine the psychosocial impact at the endocrine service, King Khalid University Hospital (KKUH) Riyadh, Saudi Arabia in the period July 2017 to June 2018. Objective: The aim of this study was to determine the psychological impact of CAH on adolescent and young women who were diagnosis and appropriately reared in the early life. Methods: Eight Saudi adolescent and young women with similar clinical characteristics where chosen from a cohort of sixty four patients with CAH. Psychosocial information were gathering during a clinic visits from both participant and parents. Participants were interviewed by the primary treating endocrinologist (principal author NJ) to facilitate trust and confidence, utilizing the child behaviour checklist (CBCL) questioner. Results: There were significant differences between females with CAH diagnosed early in life and reared as females with higher incidence of anxiety, depression (25%), withdrawn/depressed behaviour (25%) and somatic complaints (75%), which depend on the variation of the severity. Conclusion: Psychological adjustment is variable in females with CAH who were diagnosed and properly reared in early life. Adjustment depends on the severity of the disease. Future multicentre studies involving CAH patients in Saudi Arabia are needed to ensure large sample size. In addition, further researchers should concentrate on various aspects of psychosocial issues of CAH.
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