Cancer and its treatment can have a dramatic effect on women's quality of life. Aim: The aim of this study was to determine the factors that affect the quality of life of the women suffering fromgynecological cancer. Study Design:A descriptive study design. Sample size:Involved 60 women that aremedicallydiagnosed with gynecological cancer.Data collection started from November 2014 and ended at April 2015. Setting: The study was conducted at The National Cancer institute. TheToolsfor Data Collection: Involved Socio-demographic Data Assessment Tool and Quality of Life Assessment Tool (WHO, 2012) which was used to assess thefactors affectingthequality of life of women with gynecological cancer, PLISSIT model was used to collect data concerning women's response to questions. TheResults: The study results revealed that three quarters of the women had uterine cancer and the majority of the women were received management from 7months up to 5years. The most of the women in the study sample were treated by more than one type of treatment and there was a highly significant relation between the physical, psychological, social & sexual factors and the women's Quality of Life. Conclusion: The quality of life of the gynecological cancer's women is affected by physical, social, psychological & sexual factors. Recommendation:The study recommended that; a coping program should be designed and adopted for gynecological cancer's women to help them to control of the factors which affect their quality of life.