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Costridium difficile-associated diarrhea is an important complication of antibiotic use. It is in many instances hospital-acquired and affects more commonly elderly patients with significant comorbidities, accounting for a significant number of deaths. Approximately 20% of all cases of diarrhea in developed countries are estimated to be secondary to antibiotic use. The most implicated antibiotics predisposing to this condition are clindamycin, penicilins, cephalosporins and fluoroquinolones (1). In recent years the disease has become more frequent, more severe in its clinical course, more refractory to conventional therapy and more prone to recurrences (1). Once diagnosis is established, previous antibiotic treatment should be discontinued and metronidazole (250 mg orally tid or 500 mg intravenous qid) or vancomycin 125 mg qid for 7-14 days must be administered.

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