Homocysteine in one of the compounds used to induced alzheimer’s disease in rats. Hyperhomocysteinemia triggers oxidative stress, nerve inflammation and the formation of amyloid-beta in the brain. This can affect a brain region involved in appetite regulation, which leads to weight loss. This study aimed to analyzed weight changes of rats injected with homocysteine for 7, 14 and 21 days. Nine of Sprague dawley rats, aged 8-12 weeks with weight ranging between 150-200 grams, were randomly divided into three groups. The first group was injected with homocysteine for 7 days. The second and third groups received injections with homocysteine for 14 and 21 days respectively. The rats were weighed before treatment and in 7, 14, and 21 days after homocysteine injection. The average weight of rats in each group increases of 3.33±1.15, 5.00±2.00, and 2.33±3.51 grams, respectively. There was a significant difference in weight between before and after homocysteine injection for 7 days in the first group (p=0.038) and 14 days in the second group (p=0.049), while the weight of rats in the third group did not have a significant change (p=0.369). There was no significant difference in weight among the group after homocysteine injection (p=0.182). The weight of alzheimer’s model rats increased slowly after being injected with homocysteine for 7, 14, and 21 days. The low weight gain is similar to the condition of alzheimer’s patients who generally experience weight loss. It is necessary to monitor the food intake of alzheimer’s patients to prevent further weight loss.

Background: Alzheimer’s is a degenerative disease that results in decreased memory and cognitive function. The pathogenesis of Alzheimer’s disease is related to oxidative stress, which can promote damage to the brain. One of the natural ingredients that can be used as a treatment for Alzheimer’s disease is Ajwa dates. Ajwa dates contain lots of phytochemical compounds that act as antioxidants, providing a repair effect against disease.Objective: This study aimed to analyze the effect of dose and duration of Ajwa date extract administration on MDA (malondialdehyde) and SOD (superoxide dismutase) levels in Alzheimer’s model rats.Materials and Methods: Male Sprague Dawley rats, weighing 150-200 g, were orally given Ajwa date extract at dose of 200, 400 and 800 mg/kg body weight/day after the injection of homocysteine. MDA and SOD levels were measured before treatment, day seven and day 14. Data were then analyzed using the Oneway Anova test.Results: The group of Alzheimer’s rats that received Ajwa date extract for seven and 14 days experienced a decrease in MDA levels along with an increase in SOD levels compared to the control group. The group with highest doses had the same effect as the donepezil group on decreasing MDA levels and increasing SOD levels on day 14.Conclusion: Ajwa date fruit extract administration can reduce MDA levels and increase SOD levels in Alzheimer’s model rats. Ajwa dates have the potential for the treatment of Alzheimer’s disease.International Journal of Human and Health Sciences Vol. 05 No. 04 October’21 Page: 435-440