Objectives: Cultural variations complicate psychiatric care, especially for migrant children. Transcultural psychotherapy (TCP) is an original psychotherapeutic technique developed to address complex situations of resistant mental disorders in the context of migration. This research will aim to assess the efficacy, the acceptability, and describe the therapeutic processes of TCP for the treatment of depression in first or second generation of migration children and adolescents. Method: Mixed method study using a multicenter, Bayesian randomized clinical trial with blinded evaluation of the primary outcome. Two parallel groups of 40 children or adolescents from 6 to 20 years old and their family will be included. In the experimental group, patients will attend six sessions of transcultural therapy in addition to usual care. Results: The improved Clinical Global Impression scale scores at 6 months will be compared across groups. Qualitative analysis of families and therapists' interviews will allow to specify the therapeutic processes and acceptability of the therapy. Conclusion: The findings will encourage the development and routinization of TCP for second-line use and its adaption as a first-line technique in this population. K E Y W O R D S child, depression, mixed method, transcultural, treatment 1 | INTRODUCTION Migrant children represent 9.4% (47.3 million) of the European population and come, for a large part, from low-and middle-income countries. In France, one in three children born has at least one parent who comes from elsewhere and 17% of children under 18 are migrants (INSEE, 2016). This proportion continues to rise and as they may differ in physical appearance, language, religion, and culture from the nonmigrant population (Hernandez, 2010), psychiatric care of immigrated families constitutes a growing challenge in many

Background Transcultural psychotherapy (TPT) is an original therapeutic method developed in various forms in France and several other countries in Europe as well as North America to address issues of migrant mental health care when psychosocial, economic, or cultural barriers hinder its accessibility and effectiveness. This study aims to describe the patients referred for TPT in Paris and its suburbs over the past decade, to examine intercultural differences and associations with social, demographic, and clinical variables, and to assess TPT in terms of patient adherence, attendance, and duration of care. Method Retrospective study of 529 patients referred for TPT care, classified in three categories-no treatment, initiated treatment, engaged and continuing treatment. Collection and analysis of social, demographic, cultural, and clinical data, as well as of country of origin, duration of treatment, number of sessions attended (adherence), and number of sessions scheduled.

En psychiatrie transculturelle nous rencontrons des familles migrantes en souffrance psychique, pour lesquelles l’exil, les événements de vie douloureux et les difficultés liées à l’acculturation ont ébranlé les logiques culturelles. Dans ce contexte, la migration peut entraver le processus de parentalité. L’apport d’un cadre contenant et la reconnaissance symbolique des représentations des patients contribue à la construction d’une alliance thérapeutique. À partir de recherches dans ce domaine, et d’une expérience clinique transculturelle auprès d’une famille tamoule, ce travail montre l’intérêt de la mise en place progressive d’une alliance avec les membres de la famille pour accéder à leurs histoires singulières et culturelles. L’objectif est de tisser, ensemble, des liens entre les aspects culturels et individuels. Cette co-construction permettant ainsi de mobiliser la famille dans une continuité de soins et de les sensibiliser à leurs potentialités de changements.