The present study reports the optical and photophysical properties of trans-A2B-corrole possessing pyrenyl unit attached at the meso-10-position and compares it with model trans-A2B-corrole having phenyl substituent at that position....

A classical methodology to design free-base meso-tetra-(1pyrenyl)porphyrin (H 2 TPyrP) and their corresponding metalloporphyrins containing Zn(II), Cu(II), Ni(II), Co(III), and Mn(III) was described. These porphyrins were characterized in terms of structure, photophysical, and interactions profile with calfthymus deoxyribonucleic acid (CT-DNA) and bovine serum albumin (BSA). H 2 TPyrP exhibited five characteristic bands in the visible wavelength: Soret (432 nm) and Q-bands (520-650 nm range), while the metalloporphyrins showed some spectrum shifts according to the nature of the ion, which were also explored by time-dependent density functional theory (TD-DFT) calculations. The fluorescence and singlet oxygen quantum yield (Φ fl , Φ Δ , respectively) decreased with the presence of metal species in the porphyrin core. The porphyrins interact spontaneously via a ground-state association in the minor groove of CT-DNA following the increasing order of binding: CuTPyrP < H 2 TPyrP < CoTPyrP < MnTPyrP < NiTPyrP < ZnTPyrP, while for BSA the suitable complex geometry for Co(III) and Mn(III) complexes increased the binding capacity.

The Front Cover shows the design of meso‐tetra‐(1‐pyrenyl)porphyrin derivatives, which interact with biomolecules. These porphyrins were fully characterized by photophysical and theoretical methods. The presence of metal species in the porphyrin core influences the ground and excited states. Biomolecule interaction experiments show that these porphyrins interact spontaneously in the minor groove of CT‐DNA and in subdomain IB in the BSA pocket. The interaction depends on the nature of the metal ion. The cover was designed by Júlio A. F. Arvellos (scientific designer). More information can be found in the Research Article by B. Almeida Iglesias and co‐workers.