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In this paper, we complement our previous study on the antiproliferative activity of Calea fruticosa (Asteraceae) by isolating the compounds apigenin-4',7-dimethyl ether (1), budlein A (2), quercetin (3), and cichoriin (4) from the plant's aerial parts. The antiproliferative activity of these compounds was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method against human tumor cell lines. Compound 3 displayed moderate antiproliferative activity in three cell lines (HCT-116, PC-3, and SF-295, with cell growth inhibition values of 72.97, 74.55, and 68.94%) and high antiproliferative activity (90.86%) in the HL-60 cell line. The in vitro sun protection factor (SPF) of the extracts and compound 4, with and without sunscreen, was determined by a spectrophotometric method. The ethanol extract exhibited the highest SPF (9.67) at a concentration of 0.100 mg/mL, while compound 4, isolated from this extract, showed a SPF of 13.79 at the same concentration. A relative increased efficacy of SPF was observed for the extracts and compound 4 when sunscreen was also used. Compound 4 has not been reported previously from any species within the genus Calea. Compounds 1-4 were obtained from this species for the first time.

Propolis is a natural, non-toxic resin produced by honey bees that has been used for hundreds of years for its biological activities, such as antimicrobial, anti-inflammatory, anesthetic, cytostatic, and cariostatic properties. Currently, it is used in food, pharmaceutical, and cosmetic industries. The aim of this work was to evaluate the antioxidant activity, sun protection factor, and photostability of different hydroalcoholic extracts of green propolis. All extracts prepared presented high absorption in the UVB region. The extract of 70% green propolis (high temperature) was incorporated into Gel Permulen TR-1. This new formulation presented a higher value of sun protection factor. Besides that, the formulation developed with Gel Permulen TR-1 and the hydroalcoholic extract of 70% green propolis (high temperature) showed good photostability and it was safe to be applied on the skin according the HET-CAM test. These results indicated the potential of hydroalcoholic extracts of 70% green propolis (high temperature) for use in sunscreen.

Original Article silk decoction for diabetes therapy for decades (Zhao et al., 2012). Research outcomes of the ethanol extract of corn silk suggested that the antioxidant activities of corn silk could contribute, at least in part, to its traditionally claimed therapeutic benefits on diabetes mellitus and diabetic nephropathy (Wang & Zhao, 2019). In addition, corn silk is well known in treating infection and cystitis, kidney stone, nephritis and other kidney diseases (Sani, 2016). It is also used in the treatment of jaundice, measles, edema, gout, celiac hematuria, prostatitis and other diseases (Ting & Hongli, 2018;Catap et al., 2015). Its potential for use is closely related to its properties and the mechanism of action of its bioactive chemical constituents such as alkaloids, flavonoids, saponins, tannins, organic acids, phytosterols, allantoin and so on (Ren et al., 2013;Hasanudin et al., 2012). Corn silk also contains Ca 2+ , Mg 2+ , K + and Na + salts, vitamin C and K, proteins,