The TP53 R337H mutation is associated with increased incidence of pediatric adrenocortical tumor (ACT). The different environmental conditions where R337H carriers live have not been systematically analyzed. Here, the R337H frequencies, ACT incidences, and R337H penetrance for ACT were calculated using the 2006 cohort with 4165 R337H carriers living in Paraná state (PR) subregions. The effectiveness of a second surveillance for R337H probands selected from 42,438 tested newborns in PR (2016 cohort) was tested to detect early stage I tumor among educated families without periodical exams. Estimation of R337H frequencies and ACT incidence in Santa Catarina state (SC) used data from 50,115 tested newborns without surveillance, ACT cases from a SC hospital, and a public cancer registry. R337H carrier frequencies in the population were 0.245% (SC) and 0.306% (PR), and 87% and 95% in ACTs, respectively. The ACT incidence was calculated as ~6.4/million children younger than 10 years per year in PR (95% CI: 5.28; 7.65) and 4.15/million in SC (CI 95%: 2.95; 5.67). The ACT penetrance in PR for probands followed from birth to 12 years was 3.9%. R337H carriers living in an agricultural subregion (C1) had a lower risk of developing pediatric ACT than those living in industrial and large urban subregion (relative risk = 2.4). One small ACT (21g) without recurrence (1/112) was detected by the parents in the 2016 cohort. ACT incidence follows R337H frequency in each population, but remarkably environmental factors modify these rates.

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O presente artigo tem como objetivo avaliar os fatores epidemiológicos do trauma em idosos atendidos em serviços de emergência. Foi realizada uma revisão integrativa através da busca de artigos indexados na Biblioteca Virtual em Saúde, no qual após análise final foram incluídos 08 artigos. Para melhor elucidação foram formuladas duas categorias: Perfil dos idosos vítimas de trauma e Análise do evento traumático no idoso e suas implicações. Foi possível verificar que a epidemiologia do trauma no idoso atendido na emergência é multifatorial e a identificação desses componentes são consideradas ferramentas cruciais para a formulação de estratégias de prevenção.

This article aims to evaluate the epidemiological determinants of TBI in pediatric patients. An integrative review was performed by searching indexed articles in the Virtual Health Library, in which analysis after final analysis included 08 articles. For better elucidation, two categories were formulated: Epidemiological profile of children with TBI and Epidemiological determinants and the clinical implications of TBI in children. It was possible to verify that there is a male predominance, the fall is considered the main mechanism for the condition and TBI, in addition, age groups under 5 years have a worse prognosis.