Objetivos: Esta pesquisa tem como objetivo investigar a eficácia do uso da cloroquina/hidroxicloroquina no tratamento de infecções por SARS-CoV-2. Métodos: Essa pesquisa foi conduzida a partir de revisões sistemáticas e meta-análises publicadas nas principais bases de dados, até 26 de junho de 2020. Pergunta norteadora: Quais são as vantagens e malefícios do uso de cloroquina/hidroxicloroquina no tratamento de COVID-19? Resultados: Sete estudos foram incluídos, de 98 artigos selecionados na busca inicial. A hidroxicloroquina parece resultar na depuração viral com RT-PCR negativo nos seis primeiros dias de uso da medicação, e, na melhora clínica de pacientes hospitalizados com COVID-19, especialmente se associada à azitromicina. Os efeitos adversos dessa droga foram correlacionados com cardiopatias graves. A avaliação médica e o monitoramento cardiovascular diário ao longo de 14 dias foram reportados como condições mínimas para o uso da cloroquina ou da hidroxicloroquina no tratamento da COVID-19. Conclusões: Dadas as incertezas e a inexistência de um protocolo medicamentoso/terapêutico para o tratamento da COVID-19, somadas ao nível de evidência científica ser limitado, mais estudos clínicos são necessários no sentido de avaliar a indicação, segurança e efetividade da HCQ associada à azitromicina para pacientes com sintomas clínicos da COVID-19.
The aim of the present study was to evaluate knowledge regarding the conduct and adequate management of anaphylaxis on the part of oral-maxillofacial surgeons. A quantitative evaluation was performed through a cognitive survey on the subject. The sample was composed of 104 specialists and who participated in the Brazilian Oral-Maxillofacial Surgery and Traumatology Conference. A total of 31.7% of the interviewees were unaware of any protocol for anaphylaxis. Among those with information on the subject, the majority (78.8%) reported that adrenaline is the main drug for the treatment of anaphylaxis, but 50% of these individuals did not know the correct dosage and only 35.6% reported that intramuscular administration was the proper route. Only 12.5% reported having witnessed a case of anaphylaxis and all such cases were resolved with a favorable outcome. A considerable number of surgeons (34.6%) reported not having any drug for emergency care in their offices, but the majority (71.2%) reported being capable of administering such drugs. The present findings revealed a lack of knowledge on the part of many oral-maxillofacial surgeons regarding anaphylactic reactions and treatment.
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