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Four divalent metal(II) complexes, namely [Co(II)L(H2O)Cl]·2H2O, [Ni(II)L(H2O)Cl]·4H2O, [Cu(II)L(H2O)Cl]·3H2O, and [Zn(II)L(H2O)Cl]·5H2O, {L = 2‐furan‐2‐ylmethyleneamino‐phenyl‐iminomethylphenol}, were synthesized and characterized by several techniques. The molar conductance measurement of all analyzed complexes in DMSO showed their non‐electrolytic nature. The new Schiff base ligand (HL) acts as tetradentate ligand, coordinated through deprotonated phenolic oxygen, furan ring oxygen, and two azomethine nitrogen atoms. The ligand field parameters were measured for the metal complexes, which were found to be in the range notified for an octahedral structure. The molecular structural parameters of the synthesized HL ligand and its related metal(II) complexes were calculated and correlated with the experimental parameters such as infrared (IR) data. The investigated ligand and metal complexes were screened for their in vitro antimicrobial activities against different types of fungal and bacterial strains. The resulting data confirmed the examined compounds as a highly promising bactericides and fungicides. The antitumor activities of all inspected compounds were evaluated against colon carcinoma (HCT‐116) and mouse myelogenous leukemia carcinoma (M‐NFS‐60) cell lines. The inhibition effect of HL ligand and its isolated complexes on the corrosion carbon in the form of a rod of area 0.35 cm2 in HCl was investigated by measuring the weight loss at 25 °C.

Coordination compounds of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions were synthesized from the furan ligand [5-hydroxymethylfuran-2-yl-methyleneaminoquinolin-2-one] (H-MFMAQ) derived from the condensation of 5-hydroxymethylfuran-2-carbaldehyde and 1-aminoquinolin-2(1H)-one. Elemental analytical data, IR, NMR ( 1 H, 13 C, and 15 N), EPR, XRD, SEM, TEM, EDX, TGA, mass, molar conductance, magnetic moment, and UV-Visible spectra techniques were used to confirm the structure of the synthesized chelates. According to the data obtained, the composition of the 1 : 1 metal ions : furan Schiff base ligand was found to be [M(MFMAQ)Cl 2 ] (M = Cr(III) and Ru(III)) and [M(MFMAQ)Cl(H 2 O)]⋅nH 2 O in which (M = Mn(II); = 1, Co(II); = 0, Ni(II); = 2, Cu(II); = 0 and Zn(II); = 2.5). The measurements of magnetic susceptibility, ligand field parameter, and reflectance spectra suggested an octahedral geometry for the complexes. Central metals ions and furan Schiff base coordinated via O3 and N donor sites which was observed from IR spectra. The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.

A novel Schiff base ligand (H-DPPMHQ) derived from 2-hydrazineylquinoline and 1,3-diphenyl-1H-pyrazole-5-carbaldehyde and its dimeric complexes with compositions [Cr(DPPMHQ)Cl] 2 ⋅2Cl and [M(DPPMHQ)Cl] 2 (where M = Cu(II), Co(II), Ni(II) and Zn(II)) have been synthesized and characterized using physicochemical methods like elemental analysis, magnetic susceptibility and molar conductivity measurements, multispectral techniques and electrochemical studies. The molar conductance data reveal that all metal chelates are non-electrolytes, except the Cr(III) complex which shows a Λ M value of 146.82 Ω −1 cm 2 mol −1 , indicating that it is a 1:2 electrolyte. Infrared spectral results show that the metal is organized through four nitrogen atoms (azomethine and deprotonated imine groups, pyrazole and quinoline rings) besides chlorine atoms. The NH proton is also displaced during complexation, as indicated by 1 H NMR spectral data. Based on the electron spin resonance and ligand field parameter data, the bonding parameters of these complexes have been calculated. Using Coats-Redfern and Horowitz-Metzger equations, thermodynamic parameters were determined. The spectral data indicate that the dimeric complexes have octahedral geometry around the central metal ions. The cytotoxic activities of all compounds were evaluated towards human breast cancer (MCF-7) and lung cancer (A549) cell lines.