Purpose of this study is : To assess the efficacy of dynamic contrast enhanced MRI and diffusion weighted imaging in the preoperative assessment & staging of endometrial & cervical carcinoma and accordingly stratification of best treatment options. Methods The study included 40 patients having uterine malignancy 20 with endometrial carcinoma and 20 with cervical carcinoma (between 32 and 76 years) referred from Gynecologists to Radiodiagnosis Department after histologic diagnosis. Each patient was subjected to full history taking, routine laboratory investigations, preliminary trans-vaginal ultrasound and MR examination including: Conventional MRI, DCE-MRI and DWI. All cases were staged with the aid of T2WIs, DCE-MRI & DWI. Technique was performed using a standard 1.5 Tesla unit (Acheiva, Philips). Results The study showed that DCE-MRI & DWI improve the accuracy of T2WI in staging of endometrial & cervical cancer. Conclusion Using DCE-MRI & DWI improves differentiation of tumor & non-tumor tissue in cervical and endometrial cancer, thus improves the accuracy of pre-surgical mapping, assessment of treatment response and prediction of treatment outcome. That will be without increasing the expected morbidity from unnecessary procedures and accordingly increase the overall patient’s survival.

Hair dyes are widely used as cosmetic agents to color the grey hair around the world. Pphenylenediamine (PPD) induced genotoxicity due to dermal application was investigated in this study. 90 rats conducted this study and were classified into main 4 groups. Negative control group, positive control group. In-addition, two toxicity groups; short term toxicity group and long term toxicity group. Both toxicity groups were further subdivided according to PPD dose into 10 and 15 mg/kg subgroups. The results showed that repeated dermal exposure to PPD induced significant DNA damage in peripheral blood lymphocytes in dose and time dependent manner.